Tissue Engineering of Heart Valves
نویسندگان
چکیده
منابع مشابه
Advances and Trends in Tissue Engineering of Heart Valves
Improvements in health care and treatment of diseases have led to an increase in life expectancy in developed countries. However, this achievement has also inadvertently increased the prevalence of chronic illnesses such as cardiovascular disease, adding to the growing burden of health care cost globally. Unfortunately, this trend is expected to escalate in the foreseeable future. Cardiovascula...
متن کاملTissue engineering of heart valves: in vitro experiences.
BACKGROUND Tissue engineering is a new approach, whereby techniques are being developed to transplant autologous cells onto biodegradable scaffolds to ultimately form new functional tissue in vitro and in vivo. Our laboratory has focused on the tissue engineering of heart valves, and we have fabricated a trileaflet heart valve scaffold from a biodegradable polymer, a polyhydroxyalkanoate. In th...
متن کاملTissue engineering of heart valves: advances and current challenges.
It is estimated that the number of patients requiring heart valve replacement will triple over the next five decades. None of the current replacement valves can fully restore native valve function because they lack growth and remodeling capabilities. Heart valve tissue engineering is a promising technology to overcome these limitations. Various approaches are being employed, either aimed at dev...
متن کاملTissue engineering of heart valves: decellularized valve scaffolds.
In 1956, Gordon Murray first reported the human clinical surgical use of fresh aortic valve homografts (cadaveric) transplanted into the descending thoracic aorta for clinical amelioration of the consequences of native aortic valve insufficiency.1 His initial operation preceded by 5 years the availability of mechanical aortic valve prostheses. Although the operation was only partly successful h...
متن کاملTissue-engineered heart valves.
Currently-used mechanical and biological heart valve prostheses have several disadvantages. Mechanical prostheses, based on carbon, metallic and polymeric components, require permanent anticoagulation treatment, and their usage often leads to adverse reactions, e.g. thromboembolic complications and endocarditis. Xenogenous and allogenous biological prostheses are associated with immune reaction...
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ژورنال
عنوان ژورنال: Circulation
سال: 2005
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.104.473629